Gliclazide 60mg Metformin 500mg Pioglitazone Tablet

GLICLAZIDE+METFORMIN+PIOGLITAZONE contains three medicines, namely: Gliclazide, Metformin, and Pioglitazone. Gliclazide increases the production of insulin by acting on the pancreas. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects. Together GLICLAZIDE+METFORMIN+PIOGLITAZONE decreases the elevated blood sugar level after the meal along with the recommended diet and exercise. GLICLAZIDE+METFORMIN+PIOGLITAZONE also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot. GLICLAZIDE+METFORMIN+PIOGLITAZONE also helps to reduce your chance of having a heart attack or stroke. Being a combination of two drugs, it reduces the need to take multiple pills and hence makes it easier to remember to take the drugs.

Storage

Precautions and Warning

Drug Warnings

GLICLAZIDE+METFORMIN+PIOGLITAZONE may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems as their normal functioning is required to eliminate excess lactic acid from the body.  Do not consume excess alcohol as it increases the risk of lactic acidosis. It should be used with caution in patients with heart diseases as it increases the risk of heart failure.

Drug Interactions

Drug-drug interactions: Do not take the antifungal drug (miconazole and fluconazole) or iodine contrast agents (used for X-ray or scan) while using GLICLAZIDE+METFORMIN+PIOGLITAZONE. GLICLAZIDE+METFORMIN+PIOGLITAZONE may interact with medications used to treat high blood pressure like (ritodrine, salbutamol, and bosentan), bile acid sequestrants (lower cholesterol levels), drugs used to treat skin inflammation such as corticosteroids, pain killer (phenylbutazone), a medication used to treat mental illness (chlorpromazine), a medication used to reduce urine production (desmopressin), a medication used to treat endometriosis (danazol), antidiabetics (gemfibrozil), and antibiotics (rifampicin).

Drug-food interactions: Taking GLICLAZIDE+METFORMIN+PIOGLITAZONE with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycemia.

Drug-disease interactions: GLICLAZIDE+METFORMIN+PIOGLITAZONE should be avoided in patients with congestive heart failure (heart-related issues), type I diabetes, liver diseases, kidney diseases, hormonal problems, and infectious illnesses and oedema.