Metoprolol Succinate Extended Release Tablets Usp Tablet

This tablet contains Metoprolol Succinate, which is a beta-blocker medication formulated as an extended-release (SR) tablet. It is marketed under the brand name Z-MET-25 SR, indicating a 25mg strength. It is primarily used to treat high blood pressure, chest pain (angina), and heart failure, and it works by slowing down the heart rate and reducing the heart's workload to improve its function and blood flow throughout the day with a single dose.The reported volume of distribution of metoprolol is 4.2 L/kg

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Benefits of Using Metoprolol Succinate Tablets

The key benefits of consuming Metoprolol Succinate tablets are listed below:

• Effectively manages high blood pressure.
• Reduces the risk of a heart attack.
• Helps prevent future heart problems.
• Controls irregular heart rhythms (arrhythmias).
• Treats chronic heart failure.
• Improves survival after a heart attack.
• Relieves chest pain (angina).
• Slows down the heart rate to improve efficiency.
• Decreases the heart's demand for oxygen.
• Available as a generic, making it cost-effective.
• Extended-release for once-daily dosing convenience.
• Helps maintain stable blood pressure levels throughout the day.

Indications for Metoprolol Succinate Tablets

Metoprolol is indicated for the treatment of:

• Angina
• Heart failure
• Myocardial infarction
• Atrial fibrillation
• Atrial flutter
• Hypertension

Mechanism of Action

Metoprolol is a beta-1-adrenergic receptor inhibitor specific to cardiac cells with negligible effect on beta-2 receptors. This inhibition decreases cardiac output by producing negative chronotropic and inotropic effects without presenting activity towards membrane stabilization or intrinsic sympathomimetics

Dosage Instructions for Metoprolol Succinate Tablets

The instructions for using Metoprolol Succinate tablets are as follows:

• Always follow your doctor's specific dosage instructions.
• Take exactly as prescribed; do not change the dose yourself.
• Typically taken once daily.
• Can be taken with or without food.
• Swallow the tablet whole; do not crush, chew, or break it.
• Take at the same time every day for best results.
• Do not suddenly stop taking the medication.
• Your doctor may start with a low dose and adjust gradually.
• The dosage is based on your medical condition and response.
• If you miss a dose, take it as soon as you remember.
• If it is near the time of the next dose, skip the missed dose.
• Do not double the dose to catch up.
• Regularly monitor your blood pressure and heart rate.

Pharmacology Absorption for Metoprolol Succinate Tablets

The pharmacology absorption for Metoprolol Succinate tablets are:

• When metoprolol is administered orally, it is almost completely absorbed in the gastrointestinal tract 1.
• The maximum serum concentration is achieved 20 minutes after intravenous administration and 1-2 hours after oral administration. 
• The bioavailability of metoprolol is 100% when administered intravenously, and when administered orally, it presents about 50% for the tartrate derivative and 40% for the succinate derivative. 
• Metoprolol is mainly excreted via the kidneys. From the eliminated dose, less than 5% is recovered unchanged

Precautions for Metoprolol Succinate Tablets

Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing or heartbeat, shortness of breath, swelling of the face, fingers, feet, or lower legs, or weight gain. 

Do not suddenly stop taking this medicine without first checking with your doctor

Contraindications for Metoprolol Succinate Tablets

The contraindications for Metoprolol Succinate tablets are mentioned below:

• Pheochromocytoma
• Diabetes
• Low blood sugar
• Depression
• Myasthenia gravis, a skeletal muscle disorder
• Complete heart block
• Second-degree atrioventricular heart block
• Sick sinus syndrome
• Sinus bradycardia
• Sudden and serious symptoms of heart failure are called acute decompensated heart failure
• Raynaud's phenomenon, a condition where blood vessels constrict too much in response to cold or stress
• Peripheral vascular disease