Atorvastatin, Clopidogrel Bisulphate and Aspirin Capsules

Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules belong to the category of blood thinning agents and the growth of medicine that helps in the treatment of high cholesterol. These capsules are referred to in the case of prevention of heart attacks too. The occurrence is generally noticed when the blood of a person to too thick to reach the arteries. Therefore a blockage is observed within the heart channels and hence it causes heart attacks.

The Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules help in preventing blood clots as they are made using the three salters that offer a better treatment. Atorvastatin helps in reducing bad cholesterol as it belongs to the group of lipid-lowering medications. Atorvastatin and aspirin salt offer a thinning of blood, and Clopidogrel Bisulphate salt is better known to private the blood clot deposits.

Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules use need precautions too especially for regular users. Take the medicine as prescribed, avoid the intake if you are pregnant and most importantly it is not for the use of children. There are some side effects of the sat too such as drowsiness, vomiting, headache, and nausea. This is only for external use. We do not recommend these capsules kindly visit a doctor for consumption.

Working of Atorvastatin, Clopidogrel Bisulphate and Aspirin Capsules

Atorvastatin belongs to the ‘statin’ class of drugs. These drugs are used in maintaining the lipid profile and preventing the events associated with cardiovascular diseases. Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. Aspirin is used to prevent a first heart attack in people with heart disease risk factors, such as diabetes and high cholesterol.
Indications
It is indicated in the management of primary hypercholesterolemia, combined hyperlipidemia, heterozygous or homozygous familial hypercholesterolemia

Mechanism of Atorvastatin, Clopidogrel Bisulphate and Aspirin Capsules

Atorvastatin produces its action by acting as HMG Co A enzyme inhibition which converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is a precursor of cholesterol and sterols.
Clopidogrel is metabolized to its active form by carboxylesterase-1. The active form is a platelet inhibitor that irreversibly binds to P2Y12 ADP receptors on platelets. This binding prevents ADP binding to P2Y12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.

Dosage Requirement for Atorvastatin, Clopidogrel Bisulphate and Aspirin Capsules

As prescribed by the physician.

Pharmacology of Atorvastatin, Clopidogrel Bisulphate and Aspirin Capsules

Absorption
Atorvastatin attains its peak plasma concentration attains in 1-2 hrs after oral administration. The bioavailability of the drug is approximately 14%. The presence of food affects the drug availability.

A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes.

Distribution
Atorvastatin’s nearly about 98% of the drug is bound to plasma protein. The drugs produce its action by forming their metabolites.
The apparent volume of distribution of clopidogrel is 39,240±33,520L.

Excretion
After pharmacological action, Atorvastatin is excreted through bile. The elimination half-life is 14 hours.
An oral dose of radiolabelled clopidogrel is excreted 50% in the urine and 46% in the feces over 5 days.

Precautions with Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules

Here are some advisable precautions with the use of these capsules.

• Patients with hepatic dysfunction
• Increase in fasting glucose level
• In pregnant and lactating mothers
• Hypersensitivity to any of the ingredient
• In lactating and pregnant mothers

Contraindications with Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules

Some common side effects of the use are mentioned below.

• Hypersensitivity to the active substance or to any of the excipients.
• Drowsiness
• Vomiting
• Headache

Storage- Keep the Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules stored in a cool and dry place with no contact with sunlight.

Note- The Atorvastatin, Clopidogrel Bisulphate, and Aspirin Capsules are for external use.