Atorvastatin & Fenofibrat Tablets

CORAVAS-FB (Atorvastatin & Fenofibrat Tablets)

Atorvastatin+ Fenofibrate tablets are related to that class of drugs that are known as lipid-lowering medications. These medicines are used to treat high-level cholesterol in the body of patients. Additionally, this drug is also used to treat symptoms of heart disorders, and blockage of blood vessels. This combination of medicine is beneficial to treat hyperlipidemia, a kind of health issue in patients in which levels of bad cholesterol, are increased and decreased the good cholesterol. This leads patients to the risk of heart attacks, and stroke.

Atorvastatin+ Fenofibrate tablets include Atorvastatin 10mg and Fenofibrate 160 mg. Atorvastatin belongs to the ‘statin’ class of drugs. These drugs are used in maintaining the lipid profile and prevent the events associated with cardiovascular diseases.  On the other hand, fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, and lipoprotein B while increasing high-density lipoprotein cholesterol.

Product Description

Brand name: Coravas-FB

 Manufacturer: Corazon Pharma

 Composition: Atorvastatin 10mg and Fenofibrate 160 mg.

 Packaging Size:10*10

 Packaging Type: Blisters

Country of origin: India

 Treatment: High Cholesterol

 Form of Medication: Tablet

Type Of medication: Allopathic

 Usage: Medical/ Clinical

Price: 1190

Mechanism Of Action

Atorvastatin produces its action by acting as HMG Co an enzyme inhibition that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is a precursor of cholesterol and sterols. And Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPARα), increasing lipolysis, activating lipoprotein lipase, and reducing apoprotein C-III.8, 11, 12 PPARα is a nuclear receptor and its activation alters lipid, glucose, and amino acid homeostasis.

 Dosage With The Use Of Atorvastatin+ Fenofibrate Tablets

Patients should use this medication only after recommendations of professional healthcare providers, and never self-medicate the dose of medication otherwise you may face some common side effects with use.

 Pharmacology Absorption

Atorvastatin attains its peak plasma concentration attains in 1-2 hrs after oral administration. The bioavailability of the drug is approximately 14%. The presence of food affects drug availability. And on the other hand, A single 300mg oral dose of fenofibrate reaches a Cmax of 6-9.5mg/L with a Tmax of 4-6h in healthy, fasting volunteers.

Distribution Of Atorvastatin+ Fenofibrate Tablets

Atorvastatin’s nearly about 98% the drug is bound to plasma protein. The drugs produce their action by forming their metabolites. The volume of distribution of fenofibrate is 0.89L/kg,4, and can be as high as 60L.

Excretion Of Atorvastatin+ Fenofibrate Tablets

After pharmacological action atorvastatin is excreted through bile. The elimination half-life is 14 hrs.5-25% of a dose of fenofibrate is eliminated in the feces, while 60-88% is eliminated in the urine.

Tips For Safety Precautions

1. Patients with hepatic dysfunction should not use this medication.
2. This drug Increase fasting glucose level with use.
3. Pregnant and lactating mothers used the advice of a doctor.
4. This medication may show Contraindications with other drugs so be careful while using it.
5. patients with Hypersensitivity to any of the ingredients cannot use this medicine.
6. Avoid the use of alcohol with Atorvastatin+ Fenofibrate tablets.
7. Never skip the dose of drugs for treating harmful symptoms.
8. The patient should complete the course of Atorvastatin+ Fenofibrate tablets.
9. Patients should never be prescribed to other patients who are suffering from different diseases.
10. This medication is not for use in children.

Common Side Effects

Atorvastatin+ Fenofibrate tablets show many common side effects with use and the following are some adverse effects.

• Muscle pain
• Muscle weakness
• Joint pain
• Back pain
• Stuffy/runny nose or nose bleeds
• Headache
• Blurred vision
• Increased liver enzymes
• Allergic reactions
• Hyperglycemia
• Constipation
• Nausea
• Diarrhea

Contraindications

  Hypersensitivity to the active substance or to any of the excipients, and following are some names of drugs that can interact with Atorvastatin+ Fenofibrate tablets.

• TETRACYCLINE
• GENTAMICIN
• MICONAZOLE
• FLUCONAZOLE
• CYCLOSPORINE
• VERAPAMIL
• DILTIAZEM