Gliclazide Me ormin 80mg 500mg Tablet

Gliclazide 80 mg+ Metformin 500 mg tablet belongs to the class of medicines that helps in treating diabetes. It helps in treating Type 2 diabetes which is a chronic condition and cannot be cured for life. However, health issues can be managed with the use of correct pharmaceutical salts. 

People facing type 2 either face a co-dictionary under which the body reduces the production of insulin or if the production is well, the body is unable to recognize it. Under the condition blood glucose drops and irregular body symptoms such as excessive urine, sweating, thirst, and hunger may develop. Diabetics may lead to several other health problems such as low immunity, eye infections, diabetic food, and wound appearance after the intake of excessive sugar. Heart attacks and strokes are very common in diabetes. 

Gliclazide 80 mg+ Metformin 500 mg tablet is a combination of Gliclazide 80 mg and Metformin 500 mg. Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Gliclazide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release.

Metformin belongs to the biguanide classification of drugs.  It lowers glucose production in the liver, delays its absorption from the intestines, and increases the body's sensitivity to insulin. This combination helps in maintaining both fasting and post-meal sugar levels. Together, they provide better control of blood sugar.

Gliclazide 80 mg+ Metformin 500 mg tablets needs precautions. Take the tablets only under the condition of Type 2 diabetes. Consumption of sweeteners natural and artificial should be avoided. Do not consume alcohol. Maintain a healthy diet. Do not use other pharmaceutical drugs in combination. Some side faced after the consumption are vomiting drowsiness, skin dryness, increased hunger pangs, etc. 

 Indication of Gliclazide 80 mg+ Metformin 500 mg tablet

• Treatment of NIDDM
• Type 2 Diabetes Mellitus
• Dosage-  As directed by the Physician

Working Mechanism of Gliclazide 80 mg+ Metformin 500 mg tablet

Below are the details mentioned about the working mechanism of the salt. 

• Gliclazide

Gliclazide binds to the β cell sulfonylurea receptor (SUR1). This binding subsequently blocks the ATP-sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leading to depolarization of the β cells. 

• Metformin

Metformin inhibits mitochondrial complex I activity responsible for its potent ant-diabetic effect. It decreases gluconeogenesis in the liver and also decreases the intestinal absorption of glucose. It also improves the sensitivity of insulin.

Pharmacology of Gliclazide 80 mg+ Metformin 500 mg tablet

Gliclazide

• Absorption- Rapidly and well absorbed but may have wide inter- and intra-individual variability. Peak plasma concentrations occur within 4-6 hours of oral administration.
• Distribution- 94%, highly bound to plasma proteins
• Excretion- Metabolites and conjugates are eliminated primarily by the kidneys (60-70%) and also in the feces (10-20%).

Metformin

• Absorption- In the fasting condition of the patients, the drug bioavailability is about 50% to 60%. Food decreases the absorption of drugs.
• Distribution- The volume of distribution is 654±358 L. It rarely bonds to plasma protein. It does not follow hepatic metabolism.
• Excretion- It is excreted in unchanged form in urine.

Contraindication with Gliclazide 80 mg+ Metformin 500 mg tablet

Below are the important precautions required with the frequent use of Gliclazide and Metformin salt. 

• Pregnant and lactation women should avoid the use.
• People with severe kidney disease should not intake the dose.
• In the case of Metabolic acidosis or diabetic ketoacidosis, inform the doctor.
• Try to follow a healthy schedule.

Side Effects of Gliclazide 80 mg+ Metformin 500 mg tablet

The common side effects of Gliclazide and Metformin salt are mentioned below.

• Hypoglycemia 
• Taste change
• Nausea
• Diarrhea
• Stomach pain
• Headache
• Upper respiratory tract infection

Note- The Gliclazide 80 mg+ Metformin 500 mg tablets are only for external use.

Storage- Gliclazide 80 mg+ Metformin 500 mg tablet to be stored in a cool and dry place.