Glimepiride Metformin Pioglitazone 2mg 500mg 15mg

Glimepiride is a sulfonylurea anti-diabetic drug. It belongs to third-generation anti-diabetic drugs. Metformin is an oral antidiabetic drug that belongs to the biguanide class which is the first-line treatment for type 2 diabetes mellitus. It causes suppression of glucose production by the liver.Pioglitazone belongs to the class thiazolidinedione. It mainly causes hypoglycemic actions to treat diabetes.

Indication for Glimepiride Metformin Pioglitazone Salt tablets

The salt is for external use, hence it must be sued as per indicated below.

• First-line treatment for type 2 diabetes

• Metformin is used in pre-diabetes

• PCOS (polycystic ovary syndrome)

• Gastrointestinal diabetes

• Adjunct to diet and exercise

Dosage for Glimepiride Metformin Pioglitazone

As directed by the physician, do not take it without the instructions of the clinician as it may offer some side effects if taken inappropriately.

Mechanism of Glimepiride Metformin Pioglitazone Salt Tablets 

The tablets contain a variation of salts hence each one offers different values.

Glimepiride

It causes the stimulation of insulin release from pancreatic β-cells which causes the inhibition of gluconeogenesis in hepatic cells. It also increases insulin sensitivity.

Metformin

It decreases gluconeogenesis in the liver and also decreases the intestinal absorption of glucose. It also improves the sensitivity of insulin.

Pioglitazone

The drug is an agonist for PPAR receptors (peroxisome proliferator-activated receptor) which is important for insulin action. It also causes resistance to insulin in the liver which causes a decrease in hepatic glucose output.

Pharmacology of Glimepiride Metformin Pioglitazone Salt Tablets

Below we have mentioned the pharmacology of this tablet.

For Metformin

Absorption- In the fasting condition of the patients, the drug bioavailability is about 50% to 60%. Food decreases the absorption of drugs.

Distribution- The volume of distribution is 654±358 L. It rarely bonds to plasma protein. It does not follow hepatic metabolism.

Excretion- It is excreted in unchanged form in urine

For Glimepiride 

Absorption- The drug is well absorbed with peak drug concentration attaining in 2 to 3hrs. When the drug is administered with food the concentration maximum was decreased by 8%

Distribution- The drug is well distributed in the body and the volume of distribution is 8.8 L. The drug is metabolized by oxidative biotransformation. In the biotransformation of glimepiride to M1, cytochrome P450 2C9 is involved. The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2).

Excretion- About 60% of the drug is excreted through urine in seven days.

For Pioglitazone

Absorption- After oral administration, the drug attains its maximum concentration in 2 hrs.

Distribution- About 99% of the drug is bound to protein. It is metabolized by oxidation and hydroxylation.

Excretion- About 15-30% of the drug is excreted through urine.

Precautions with Glimepiride Metformin Pioglitazone Salt Tablets

The important precaution with the use of salt is mentioned below.

• Use is contraindicated in the pregnant patient

• In lactating mothers

• Renal dysfunction

• Patient undergoing radiological studies

• Acute or chronic metabolic acidosis

• Hypersensitivity to any of the ingredients.

• Avoid alcohol consumption

Storage- Keep the Glimepiride Metformin Pioglitazone salt tablets stored in a cool and dry place.

Note- Glimepiride Metformin Pioglitazone salt tablets are only for external use.